A young African American Young cotton picker in Arkansas during the Depression.
Photograph by Bobby Doherty for TIME
Many people with depression or anxiety are being prescribed emotional support animals: dogs, cats, pigs, hedgehogs and, yes, iguanas.
Bettmann / Corbis
A Great Depression–era employment agency is crowded with men seeking work
Horses can lapse into apparent depression when they lose a companion.
RR Auction / Handout / Reuters
Two pistols found on the bodies of famed Depression-era outlaws Bonnie Parker and Clyde Barrow after they were killed by a posse in 1934 have sold at auction for a total of $504,000 in Nashua, N.H., Sept. 30, 2012.
ILLUSTRATION FOR TIME BY STEVEN BRAY
Does our treatment of depression cause more misery?
Clara Cannucciari, 95, creator and star of Great Depression Cooking With Clara.
Q. Sakamaki / Redux
"Shades of the past:" Echoing scenes from the Great Depression, New York City street performers lampoon Wall Street bailouts
Gillian Laub for TIME
Gillian helped pull Sam Cila of Riverhead, N.Y., out of a deep depression after an IED in Iraq cost him his hand
Archive Photos / Getty
A bread line forms outside the Rescue Society on Doyers Street in New York City during the Great Depression
Margaret Bourke-White—Time & Life Pictures/Getty Images
During the Great Ohio River Flood of 1937, at the height of the Great Depression, African Americans in Louisville, Kentucky, line up seeking food and clothing from a relief station, in front of a billboard ironically proclaiming, "World's Highest Standard of Living."